Fainters, pull up your socks!

Pull up transistor folding

We develop a polynomial time algorithm for the pull up transistor assignment problem and show that the interval selection and interval selection with pull up transistor assignment problems are N P hard. Heuristics for these problems are proposed and compared with that proposed in 1111.

Wake up your patients!

In 1998, Thomas L. Petty expressed his concern about deep sedation and suggested a new link between sedation and severe complications.(1) His phrasing emphasized that it is not the underlying disease, but the physicians themselves that cause the gloomy situation he experienced in his intensive care unit (ICU). As more evidence supporting his theory has emerged, Petty’s editorial seems even more...

Tubulogenesis: Zipping up Your Fly

In animals, rearrangements of the junctions between cells are fundamental to morphogenesis. Recent work has revealed the acrobatics that Drosophila tracheal cells perform as they intercalate to form unicellular tubes.

Adaptive immune responses in atherosclerosis or how to prolong the use of your yellow socks

An ACE Up Your Sleeve

Although the renin angiotensin system (RAS) is a well established regulator of blood pressure and intravascular volume,1 considerable evidence has emerged demonstrating the importance of the RAS directly on the cardiovascular system (please refer to the Figure for description of the enzymatic pathways involved in RAS regulation). Indeed, angiotensin converting enzyme (ACE) inhibitors, which pre...